|
Symbol Name ID |
Stat6
signal transducer and activator of transcription 6 MGI:103034 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Mouse Phenotypes | immune system phenotype |
increased B cell apoptosis |
impaired eosinophil chemotaxis |
impaired neutrophil chemotaxis |
abnormal leukocyte migration |
abnormal B cell proliferation |
decreased B cell proliferation |
decreased T cell proliferation |
abnormal class switch recombination |
abnormal CD4-positive T cell differentiation |
abnormal T-helper 1 cell differentiation |
abnormal T-helper 2 cell differentiation |
abnormal mast cell morphology |
decreased T-helper 2 cell number |
abnormal CD8-positive, alpha beta T cell morphology |
abnormal leukocyte physiology |
abnormal granulocyte physiology |
impaired eosinophil recruitment |
abnormal B cell physiology |
abnormal immunoglobulin level |
decreased IgA level |
increased IgA level |
decreased IgE level |
increased IgE level |
decreased IgG1 level |
increased IgG1 level |
increased IgG2a level |
decreased IgG3 level |
increased IgG level |
decreased IgM level |
abnormal T-helper 2 physiology |
abnormal cytotoxic T cell physiology |
abnormal macrophage physiology |
abnormal circulating interleukin level |
abnormal circulating interleukin-4 level |
abnormal circulating interleukin-5 level |
increased circulating tumor necrosis factor level |
abnormal level of surface class II molecules |
abnormal humoral immune response |
abnormal immune serum protein physiology |
abnormal cytokine secretion |
increased interferon-gamma secretion |
abnormal interleukin secretion |
increased interleukin-12 secretion |
increased interleukin-2 secretion |
decreased interleukin-4 secretion |
decreased interleukin-5 secretion |
decreased susceptibility to autoimmune diabetes |
abnormal acute inflammation |
skin inflammation |
increased susceptibility to parasitic infection |
decreased susceptibility to Herpesvirales infection |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stat6tm1Aki/Stat6tm1Aki | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stat6tm1Gru/Stat6tm1Gru | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stat6tm1Jni/Stat6tm1Jni | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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